Tell your opinion and why?

For me its the Campbellsville and Lou Holy Cross game. Can a young Campbellsville team beat a very solid Holy Cross team a second time? Will the young Eagle players get to play for a regional title game? Will Holy Cross come out and get the win to push into a regional final? Just a really fun game to try and figure out how it will play out. 

I think Bishop Brossart/Paintsville. Brossart's improvement over the last decade has been impressive but they've yet to beat a name program in Class 1A. Paintsville, while not great this season, was a state champion a couple of years ago. Bishop Brossart is very close to cracking into that upper echelon of the class; a win here is a giant step forward.

I think there are several interesting match-ups.

Crittenden County (7-4) vs. Bethlehem (8-2) - Bethlehem won the regular season match-up, but many times the second time is a little harder.  

Campbellsville (7-3) vs.  Louisville Holy Cross (8-3) - Campbellsville won the regular season game by 5, but, like above, the second time is a little harder. 

Bishop Brossart (9-2) vs. Paintsville (5-5) - I just expect a good game between these two schools.   

Brossart and Paintsville. For many of the same reasons @gchs_uk9 said above. Brossarts defense has been lights out lately and this could be their toughest test in quite a few weeks, if not all year.