The favorite has to be Johnson Central. However, you are right several teams could win it!
Prestonsburg is very athletic, (Williams, Jarrell & Frasier) but would have to play WAY over their heads to beat Johnson Central with their talent (Hall, Blair ect...).
Pikeville & Pike Co Central is an old rivalry from the 59th district days and for that reason could be a good game, but PCC would have to play GREAT to win over (Rowe, Kasongo & company).
The bottom bracket will be a dog fight! Betsy Layne & Sheldon Clark should be a good game, with guard play deciding the outcome.
Belfry & East Ridge being a game of guard play (Miller) vs big man (Messer) deciding this one.
If Johnson Central & Pikeville advance it will setup a great semi finals round no matter who advances in bottom bracket two games the teams will be evenly matched.
In the finals the winner between Johnson Central/Pikeville will be the favorite but at that point it only takes one good game to get you to Rupp.
Could be VERY interesting!!!